The effects of a higher protein intake during energy restriction on changes in body composition and physical function in older women

J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1218-25. doi: 10.1093/gerona/glr120. Epub 2011 Jul 27.

Abstract

Background: The purpose of this double-blind randomized clinical trial was to compare the relative effectiveness of a higher protein and conventional carbohydrate intake during weight loss on body composition and physical function in older women.

Methods: Thirty-one overweight or obese, postmenopausal women (mean ± SD: age 65.2 ± 4.6 years, body mass index 33.7 ± 4.9 kg/m(2)) were prescribed a reduced calorie diet (1,400 kcal/day; 15%, 65%, 30% energy from protein, carbohydrate, and fat, respectively) and randomly assigned to 2 × 25 g/day whey protein (PRO n = 15) or maltodextrin (CARB n = 16) supplementation for 6 months. Lean soft tissue (LST) via dual-energy X-ray absorptiometry; thigh muscle, subcutaneous adipose tissue (SAT), and intermuscular adipose tissue with magnetic resonance imaging; knee strength with isokinetic dynamometry; balance and physical function with a battery of performance tests.

Results: PRO lost more weight than CARB (-8.0% ± 6.2%, -4.1% ± 3.6%, p = .059; respectively). Changes in LST, %LST, and strength, balance, or physical performance measures did not differ between groups (all p > .05). Weight to leg LST ratio improved more in PRO versus CARB (-4.6 ± 3.6%, -1.8 ± 2.6%, p = .03). PRO lost 4.2% more muscle (p = .01), 10.9% more SAT (p = .02), and 8.2% more intermuscular adipose tissue (p = .03) than CARB. Relative to thigh volume changes, PRO gained 5.8% more muscle (p = .049) and lost 3.8% greater SAT (p = .06) than CARB. Weight to leg LST ratio (r(2) = .189, p = .02) and SAT (r(2) = .163, p = .04) predicted improved up and go, relative muscle (r(2) = .238, p = .01) and SAT (r(2) = .165, p = .04) predicted improved transfer test, and %LST predicted improved balance (r(2) = .179, p = .04).

Conclusions: A higher protein intake during caloric restriction maintains muscle relative to weight lost, which in turn enhances physical function in older women.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Body Composition / physiology*
  • Caloric Restriction*
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Proteins / administration & dosage*
  • Double-Blind Method
  • Exercise / physiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Muscle Strength
  • Muscle, Skeletal / physiology
  • Weight Loss / physiology*

Substances

  • Dietary Carbohydrates
  • Dietary Proteins