Evidence for network evolution in an Arabidopsis interactome map

Science. 2011 Jul 29;333(6042):601-7. doi: 10.1126/science.1203877.

Abstract

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 14-3-3 Proteins / metabolism
  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Evolution, Molecular
  • Genes, Plant
  • Plant Growth Regulators / metabolism
  • Protein Interaction Mapping*
  • Proteome
  • Signal Transduction
  • Transcription Factors / metabolism
  • Ubiquitination

Substances

  • 14-3-3 Proteins
  • Arabidopsis Proteins
  • Plant Growth Regulators
  • Proteome
  • Transcription Factors