Serial measurement of tear meniscus by FD-OCT after instillation of artificial tears in patients with dry eyes

Ophthalmic Surg Lasers Imaging. 2011 Jul-Aug;42(4):308-13. doi: 10.3928/15428877-20110603-02.


Background and objective: To use Fourier-domain optical coherence tomography (FD-OCT) to study the effect of artificial tears on the tear meniscus in patients with dry eyes.

Patients and methods: The lower tear meniscus of 16 consecutive patients with dry eyes was imaged by an FD-OCT system (RTVue; Optovue, Inc., Fremont, CA). Baseline and five serial pairs of measurements were taken after the instillation of artificial tears (Optive; Allergan, Irvine, CA) at 1, 2, 5, 10, and 15 minutes. The lower meniscus height, depth, and area were measured with a computer caliper.

Results: Baseline meniscus measurements were 235.5 ± 150.0 μm, 138.1 ± 78.7 μm, and 0.020 ± 0.022 mm(2) for height, depth, and area, respectively. After instillation of artificial tears, all lower tear meniscus parameters remained significantly elevated for 5 minutes and returned to baseline by 10 minutes.

Conclusion: FD-OCT is able to quantify a dramatic initial increase in tear meniscus, followed by a decay back to baseline values after approximately 5 minutes. FD-OCT may be useful in objectively quantifying the dynamic efficacy of dry eye treatments.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dry Eye Syndromes / drug therapy*
  • Dry Eye Syndromes / metabolism*
  • Female
  • Fourier Analysis*
  • Humans
  • Male
  • Middle Aged
  • Ophthalmic Solutions / administration & dosage*
  • Prospective Studies
  • Tears / metabolism*
  • Tomography, Optical Coherence*


  • Ophthalmic Solutions