Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm

Epilepsia. 2011 Sep;52(9):e118-22. doi: 10.1111/j.1528-1167.2011.03200.x. Epub 2011 Jul 29.


Pilocarpine-induced status epilepticus (SE) results in chronic spontaneous recurrent seizures resembling human temporal lobe epilepsy. In this and other experimental models, behaviorally monitored seizure frequency was suggested to vary in a circadian fashion, and to increase with time. We re-addressed those hypotheses using continuous video-electroencephalography (EEG) telemetry in rats with SE at 30 days of age. In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chi-Square Distribution
  • Circadian Rhythm / drug effects
  • Circadian Rhythm / physiology*
  • Disease Models, Animal
  • Electroencephalography
  • Male
  • Pilocarpine / toxicity*
  • Rats
  • Rats, Wistar
  • Seizures / etiology*
  • Status Epilepticus / chemically induced
  • Status Epilepticus / complications*


  • Pilocarpine