Abstract
Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.
MeSH terms
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Bucladesine / pharmacology
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CD13 Antigens / metabolism
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Cell Line*
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Decidua / drug effects
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Decidua / physiology
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Down-Regulation
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Endometrium / cytology*
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Estradiol / pharmacology
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Female
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Humans
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Interleukin-1beta / pharmacology
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Medroxyprogesterone Acetate / pharmacology
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Middle Aged
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Neprilysin / metabolism
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Receptors, Estrogen / biosynthesis
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Receptors, Progesterone / biosynthesis
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Stromal Cells / drug effects
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Stromal Cells / physiology*
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Vimentin / metabolism
Substances
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Interleukin-1beta
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Receptors, Estrogen
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Receptors, Progesterone
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Vimentin
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Estradiol
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Bucladesine
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Medroxyprogesterone Acetate
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CD13 Antigens
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Neprilysin