A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo

Chem Biol. 2011 Jul 29;18(7):833-8. doi: 10.1016/j.chembiol.2011.07.003.


We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, White / metabolism
  • Animals
  • Cell Line
  • Cytosol / metabolism*
  • Databases, Protein
  • Humans
  • Mice
  • Models, Molecular
  • Pancreas / metabolism
  • Protein Transport
  • Proteins / administration & dosage*
  • Proteins / chemistry
  • Proteins / metabolism*
  • Recombinant Fusion Proteins / administration & dosage
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / metabolism
  • Retina / metabolism


  • Proteins
  • Recombinant Fusion Proteins