Understanding obesity and endometrial cancer risk: opportunities for prevention

Am J Obstet Gynecol. 2011 Dec;205(6):518-25. doi: 10.1016/j.ajog.2011.05.042. Epub 2011 Jun 7.


Worldwide, obesity has become a major public health crisis. Overweight and obesity not only increase the risk of cardiovascular disease and type-2 diabetes mellitus but also are now known risk factors for a variety of cancer types. Among all cancers, increasing body mass index is associated most strongly with endometrial cancer incidence and death. The molecular mechanisms underlying how adipose tissue and obesity contribute to the pathogenesis of endometrial cancer are becoming better understood and have revealed a number of rational strategies, both behavioral and pharmaceutical, for the prevention of both primary and recurrent disease.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Endometrial Neoplasms / epidemiology*
  • Endometrial Neoplasms / physiopathology
  • Endometrial Neoplasms / prevention & control*
  • Female
  • Humans
  • Incidence
  • Obesity / epidemiology*
  • Obesity / physiopathology
  • Risk Factors