Flaxseed Dietary Fibers Suppress Postprandial Lipemia and Appetite Sensation in Young Men

Nutr Metab Cardiovasc Dis. 2013 Feb;23(2):136-43. doi: 10.1016/j.numecd.2011.03.004. Epub 2011 Jul 29.

Abstract

Background and aim: Dietary fibers (DF) are linked to a reduced risk of life-style diseases, which relate to their physiological effects in the gastrointestinal tract. The aim was to examine whether flaxseed DF-enriched meals suppress postprandial lipemia and reduce appetite.

Methods and results: Four different iso-caloric meals were tested in 18 young men in a double-blind randomized crossover design. Test meals were served after an overnight fast. DF content and source were: control (C): 1.4 g/MJ; whole flaxseed (WF): 2.4 g/MJ from whole flaxseeds; low-mucilage dose (LM): 2.4 g/MJ from flaxseed DF; high-mucilage dose (HM): 3.4 g/MJ from flaxseed DF. During the 7 h test day, subjective appetite sensation was assessed using visual analogue scales and appetite-regulating hormones, and lipemia and glycemia were measured, after which ad libitum energy intake was recorded. There was a significant time × meal effect on triacylglycerols (TG) (p = 0.02) and an 18% smaller area under the curve (AUC) for TG after meal HM compared to meal C was observed (p < 0.01). AUC for insulin was smaller after both LM and HM meals compared to C and WF meals. Higher mean ratings of satiety (p < 0.01) and fullness (p = 0.03) was seen following the HM meal compared to meal C. AUC for ghrelin, CCK and GLP-1 and ad libitum energy intake did not differ between meals, but ghrelin response exhibited a different response pattern after the mucilage-containing meals.

Conclusion: These findings suggest that flaxseed DF may suppress postprandial lipemia and appetite although subsequent energy intake was not affected.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Appetite / drug effects*
  • Blood Glucose / analysis
  • Cross-Over Studies
  • Dietary Fiber / administration & dosage*
  • Double-Blind Method
  • Energy Intake
  • Flax / chemistry*
  • Ghrelin / blood
  • Glucagon-Like Peptide 1 / blood
  • Humans
  • Hyperlipidemias / drug therapy*
  • Insulin / blood
  • Male
  • Postprandial Period / drug effects*
  • Satiation / drug effects*
  • Triglycerides / blood
  • Young Adult

Substances

  • Blood Glucose
  • Dietary Fiber
  • Ghrelin
  • Insulin
  • Triglycerides
  • Glucagon-Like Peptide 1