The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae

Phytomedicine. 2011 Nov 15;18(14):1262-8. doi: 10.1016/j.phymed.2011.06.010. Epub 2011 Jul 30.


The effect of aqueous extract from R. rosea root on lifespan and the activity of antioxidant enzymes in budding yeast Saccharomyces cerevisiae have been studied. The supplementation of the growth medium with R. rosea extract decreased survival of exponentially growing S. cerevisiae cells under H(2)O(2)-induced oxidative stress, but increased viability and reproduction success of yeast cells in stationary phase. The extract did not significantly affect catalase activity and decreased SOD activity in chronologically aged yeast population. These results suggest that R. rosea acts as a stressor for S. cerevisiae cells, what sensitizes yeast cells to oxidative stress at exponential phase, but induces adaptation in stationary phase cells demonstrating the positive effect on yeast survival without activation of major antioxidant enzymes.

MeSH terms

  • Adaptation, Physiological
  • Catalase / chemistry
  • Colony Count, Microbial
  • Culture Media / chemistry
  • Enzyme Activation
  • Enzyme Assays
  • Glucosides / chemistry
  • Glucosides / pharmacology
  • Hydrogen Peroxide / pharmacology
  • Microbial Viability
  • Oxidative Stress*
  • Phenols / chemistry
  • Phenols / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry*
  • Rhodiola / chemistry*
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / growth & development
  • Superoxide Dismutase / chemistry
  • Time Factors
  • Water / chemistry


  • Culture Media
  • Glucosides
  • Phenols
  • Plant Extracts
  • Water
  • Hydrogen Peroxide
  • Catalase
  • Superoxide Dismutase
  • rhodioloside