Diverse roles of the Mediator complex in plants

Semin Cell Dev Biol. 2011 Sep;22(7):741-8. doi: 10.1016/j.semcdb.2011.07.012. Epub 2011 Jul 23.


Since its original discovery in yeast, the Mediator complex has been identified in a wide range of organisms across the eukaryotic kingdom. Despite being experimentally purified from a number of fungal and metazoan organisms, it was not until 2007, thirteen years after its initial discovery, that the Mediator complex was successfully isolated from plants. With a number of papers now beginning to emerge on the plant Mediator complex, this review aims to provide an overview of the diverse functions that have been identified for individual plant Mediator subunits. In addition to demonstrating roles in plant development, flowering, hormone signaling and biotic and abiotic stress tolerance; recent findings have revealed novel functions for plant Mediator subunits, including mRNA, miRNA and rRNA processing, as well as controlling DNA and protein stability. These diverse activities have expanded the known functions of the Mediator complex and demonstrate a variety of new insights that have been gained from investigations into the plant Mediator complex. Future directions for research into this multi-functional protein complex will be discussed.

Publication types

  • Review

MeSH terms

  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • DNA-Binding Proteins
  • Flowers / metabolism
  • Mediator Complex / genetics*
  • Mediator Complex / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Plant Development
  • Plants / genetics*
  • Plants / metabolism*
  • RNA Processing, Post-Transcriptional
  • RNA, Untranslated / biosynthesis
  • Signal Transduction
  • Stress, Physiological
  • Transcription, Genetic


  • Arabidopsis Proteins
  • DNA-Binding Proteins
  • Mediator Complex
  • Nuclear Proteins
  • PFT1 protein, Arabidopsis
  • RNA, Untranslated