Iodine-131-labeled meta-iodobenzylguanidine therapy of children with neuroblastoma: program planning and initial experience

Semin Nucl Med. 2011 Sep;41(5):354-63. doi: 10.1053/j.semnuclmed.2011.06.001.


Patients with high-risk neuroblastoma have a poor prognosis, especially in cases of recurrent or relapsed disease. Iodine-131-labeled meta-iodobenzylguanidine ((131)I-MIBG) can be an effective and relatively well-tolerated agent for the treatment of refractory neuroblastoma. Establishing an MIBG therapy program requires a great deal of planning, availability of hospital resources, and the commitment of individuals with training and expertise in multiple disciplines. Providing (131)I-MIBG therapy requires physical facilities and procedures that permit patient care in compliance with the standards for occupational and community exposure to radiation. Establishment of a successful (131)I-MIBG therapy program also requires a detailed operational plan and appropriate education for caregivers, parents, and patients.

Publication types

  • Review

MeSH terms

  • 3-Iodobenzylguanidine / therapeutic use*
  • Child
  • Combined Modality Therapy
  • Education
  • Humans
  • Neuroblastoma / radiotherapy*
  • Radiotherapy / adverse effects
  • Radiotherapy / instrumentation
  • Radiotherapy / methods*


  • 3-Iodobenzylguanidine