Anaerobicizing into pluripotency

Cell Metab. 2011 Aug 3;14(2):143-4. doi: 10.1016/j.cmet.2011.07.003.


Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence to suggest that these changes may precede pluripotency.

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