Electrical synapses formed by connexin36 regulate inhibition- and experience-dependent plasticity

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13770-5. doi: 10.1073/pnas.1100166108. Epub 2011 Jul 29.


The mammalian brain constantly adapts to new experiences of the environment, and inhibitory circuits play a crucial role in this experience-dependent plasticity. A characteristic feature of inhibitory neurons is the establishment of electrical synapses, but the function of electrical coupling in plasticity is unclear. Here we show that elimination of electrical synapses formed by connexin36 altered inhibitory efficacy and caused frequency facilitation of inhibition consistent with a decreased GABA release in the inhibitory network. The altered inhibitory efficacy was paralleled by a failure of theta-burst long-term potentiation induction and by impaired ocular dominance plasticity in the visual cortex. Together, these data suggest a unique mechanism for regulating plasticity in the visual cortex involving synchronization of inhibitory networks via electrical synapses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Connexins / physiology*
  • Electrical Synapses*
  • Inhibitory Postsynaptic Potentials
  • Long-Term Potentiation
  • Mice
  • Neuronal Plasticity / physiology*
  • Synaptic Transmission / physiology*
  • Theta Rhythm
  • Visual Cortex
  • gamma-Aminobutyric Acid


  • Connexins
  • connexin 36
  • gamma-Aminobutyric Acid