Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa

Shoji Maehara; Michiteru Ikeda; Hiroyuki Haraguchi; Chinami Kitamura; Tetsuro Nagoe; Kazuyoshi Ohashi; Hirotaka Shibuya

doi:10.1248/cpb.59.1042

Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa

Chem Pharm Bull (Tokyo). 2011;59(8):1042-4. doi: 10.1248/cpb.59.1042.

Authors

Shoji Maehara¹, Michiteru Ikeda, Hiroyuki Haraguchi, Chinami Kitamura, Tetsuro Nagoe, Kazuyoshi Ohashi, Hirotaka Shibuya

Affiliation

¹ Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.

PMID: 21804251
DOI: 10.1248/cpb.59.1042

Abstract

We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ascomycota / chemistry
Ascomycota / metabolism*
Curcuma / microbiology*
Curcumin / analogs & derivatives*
Curcumin / metabolism*
Rhizome / microbiology*

Substances

Curcumin