A critical period for auditory thalamocortical connectivity

Nat Neurosci. 2011 Jul 31;14(9):1189-94. doi: 10.1038/nn.2882.


Neural circuits are shaped by experience during periods of heightened brain plasticity in early postnatal life. Exposure to acoustic features produces age-dependent changes through largely unresolved cellular mechanisms and sites of origin. We isolated the refinement of auditory thalamocortical connectivity by in vivo recordings and day-by-day voltage-sensitive dye imaging in an acute brain slice preparation. Passive tone-rearing modified response strength and topography in mouse primary auditory cortex (A1) during a brief, 3-d window, but did not alter tonotopic maps in the thalamus. Gene-targeted deletion of a forebrain-specific cell-adhesion molecule (Icam5) accelerated plasticity in this critical period. Consistent with its normal role of slowing spinogenesis, loss of Icam5 induced precocious stubby spine maturation on pyramidal cell dendrites in neocortical layer 4 (L4), identifying a primary locus of change for the tonotopic plasticity. The evolving postnatal connectivity between thalamus and cortex in the days following hearing onset may therefore determine a critical period for auditory processing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation / methods
  • Action Potentials / physiology
  • Age Factors
  • Amino Acids / metabolism
  • Analysis of Variance
  • Animals
  • Animals, Newborn
  • Auditory Cortex / physiology*
  • Auditory Pathways / physiology
  • Auditory Perception / physiology
  • Critical Period, Psychological*
  • Evoked Potentials, Auditory / physiology*
  • In Vitro Techniques
  • Membrane Glycoproteins / metabolism
  • Mice
  • Nerve Tissue Proteins / metabolism
  • Patch-Clamp Techniques
  • Sound
  • Thalamus / physiology*


  • Amino Acids
  • Icam5 protein, mouse
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • dolaisoleucine