Pulse transit time in screening sleep disordered breathing in an elderly population: the PROOF-SYNAPSE study

Sleep. 2011 Aug 1;34(8):1051-9. doi: 10.5665/SLEEP.1160.


Study objectives: Pulse transit time (PPT) has been introduced as a useful screening tool to diagnose sleep disordered breathing (SDB). Since the prevalence of SDB increases with age, the question is whether PTT could be used to diagnose SDB in the elderly. We assess the effectiveness of PTT for SDB screening in a large healthy elderly population.

Setting: Community-based sample in home and research clinical settings.

Intervention: N/A.

Participants: Seven hundred eighty volunteers, free of cardiac and neurologic disease, aged 68.6 ± 1.0 years, underwent ambulatory polygraphy to measure the apnea-hypopnea index (AHI). The presence of SDB was defined as an AHI of 15 or greater. The PTT was continuously monitored during the nocturnal study, and the overall autonomic arousal index (AAI) was calculated.

Results: SDB was diagnosed in 447 (57.3%) subjects. In these subjects, the Bland-Altman plot for AAI revealed an underestimation with a bias of -8.04 ± 16.55 events per hour (mean ± 95% confidence interval). Receiver operating characteristic curves constructed for an AHI of 15 or greater defined an area under the curve of 0.67 and a cutoff point to AAI 32.3 events per hour, giving a sensitivity of 70.5% and a specificity of 54.7%. For prediction of an AHI of at least 30, the area under the curve was equal to 0.74 for a cutoff point of 56.3 events per hour, giving a better specificity (94.7%) but a lower sensitivity (32.2%).

Conclusions: In a healthy older population, the AAI showed moderate sensitivity for predicting SDB. This data does not allow us to use PTT as a screening tool for the diagnosis of SDB in the elderly.

Clinical trial registration: NCT 00759304 and NCT 00766584.

Trial registration: ClinicalTrials.gov NCT00759304 NCT00766584.

Keywords: Sleep-disordered breathing; aging; arousal; autonomic function; screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Electrocardiography / methods*
  • Electrocardiography / statistics & numerical data
  • Female
  • Geriatric Assessment / methods
  • Geriatric Assessment / statistics & numerical data
  • Humans
  • Longitudinal Studies
  • Male
  • Polysomnography / methods
  • Polysomnography / statistics & numerical data
  • Predictive Value of Tests
  • ROC Curve
  • Sensitivity and Specificity
  • Sleep Apnea Syndromes / diagnosis*
  • Sleep Apnea Syndromes / physiopathology

Associated data

  • ClinicalTrials.gov/NCT00759304
  • ClinicalTrials.gov/NCT00766584