Infliximab induces increase in triglyceride levels in psoriatic arthritis patients

Clin Dev Immunol. 2011;2011:352686. doi: 10.1155/2011/352686. Epub 2011 Jul 24.

Abstract

Objectives: To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA).

Methods: Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included. None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated.

Results: The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8 ± 49.7 versus 140.1 ± 64.1 mg/dL, P = 0.028) and VLDL-c (23.6 ± 10.5 versus 28.4 ± 13.7 mg/dL, P = 0.019) levels. In contrast, there were no differences in the mean TC (P = 0.28), LDL-c (P = 0.42), and HDL-c (P = 0.26) levels. Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P > 0.05). Positive correlations were found between VLDL-c and CRP (r = 0.647, P = 0.009) and between triglycerides and CRP (r = 0.604, P = 0.017) levels at 3M. ESR reduction was observed after 3M (P = 0.04). Mean prednisone dose remained stable at beginning and at 3M (P = 0.37).

Conclusion: This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / therapeutic use
  • Antirheumatic Agents / administration & dosage*
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Psoriatic / blood
  • Arthritis, Psoriatic / drug therapy*
  • Arthritis, Psoriatic / pathology
  • C-Reactive Protein / analysis
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cholesterol, VLDL / analysis
  • Cholesterol, VLDL / blood
  • Female
  • Humans
  • Infliximab
  • Lipid Metabolism / drug effects*
  • Male
  • Middle Aged
  • Prednisone / administration & dosage
  • Prospective Studies
  • Triglycerides / blood

Substances

  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cholesterol, VLDL
  • Triglycerides
  • C-Reactive Protein
  • Infliximab
  • Prednisone