Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues

Beilstein J Org Chem. 2011:7:678-98. doi: 10.3762/bjoc.7.80. Epub 2011 May 26.

Abstract

This review article summarizes the results of a long-term investigation of 5-alkoxymethyluracil analogues and is aimed, in particular, at methods of syntheses. Most of the presented compounds were synthesized in order to evaluate their biological activity, therefore, a brief survey of biological activity, especially antiviral, cytotoxic and antibacterial, is also reported.

Keywords: 5-alkoxymethyluracil; biological activity; nucleosides.