Impact of the Penicillium chrysogenum genome on industrial production of metabolites

Appl Microbiol Biotechnol. 2011 Oct;92(1):45-53. doi: 10.1007/s00253-011-3476-z. Epub 2011 Jul 30.


The genome sequence of Penicillium chrysogenum has initiated a range of fundamental studies, deciphering the genetic secrets of the industrial penicillin producer. More than 60 years of classical strain improvement has resulted in major but delicate rebalancing of the intracellular metabolism leading to the impressive penicillin titres of the current production strains. Several leads for further improvement are being followed up, including the use of P. chrysogenum as a cell factory for other products than β-lactam antibiotics.

Publication types

  • Review

MeSH terms

  • Biotechnology / methods*
  • Genetic Engineering
  • Genome, Fungal*
  • Metabolic Engineering / methods*
  • Metabolic Networks and Pathways / genetics*
  • Penicillium chrysogenum / genetics*
  • Penicillium chrysogenum / metabolism*