Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis

Can J Physiol Pharmacol. 2011 Aug;89(8):533-7. doi: 10.1139/y11-051. Epub 2011 Aug 2.


The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) is an important and extremely sensitive marker for specific regions of the developing heart, as well as for disturbances in the patterning of the heart. This review summarizes the dynamic expression of ANF in the developing heart and its usefulness in understanding the early molecular defects underlying CHDs.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Atrial Natriuretic Factor / genetics
  • Atrial Natriuretic Factor / metabolism
  • Atrial Natriuretic Factor / physiology*
  • Heart / embryology*
  • Heart / physiology*
  • Heart Defects, Congenital / genetics
  • Heart Defects, Congenital / metabolism
  • Humans
  • Morphogenesis / physiology


  • Atrial Natriuretic Factor