Pathways Underlying the Gut-To-Brain Connection in Autism Spectrum Disorders as Future Targets for Disease Management

Eur J Pharmacol. 2011 Sep;668 Suppl 1:S70-80. doi: 10.1016/j.ejphar.2011.07.013. Epub 2011 Jul 27.

Abstract

Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain* / immunology
  • Brain* / metabolism
  • Child
  • Child Development Disorders, Pervasive / complications
  • Child Development Disorders, Pervasive / immunology
  • Child Development Disorders, Pervasive / metabolism
  • Child Development Disorders, Pervasive / therapy*
  • Gastrointestinal Tract* / metabolism
  • Gastrointestinal Tract* / pathology
  • Humans
  • Molecular Targeted Therapy / methods*
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • TOR Serine-Threonine Kinases