Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production

J Med Food. 2011 Sep;14(9):899-906. doi: 10.1089/jmf.2010.1363. Epub 2011 Aug 3.


Royal jelly (RJ) is a honeybee product containing proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. As its principal unsaturated fatty acid, RJ contains 10-hydroxy-2-decenoic acid (10-HDA), which may have antitumor and antibacterial activity and a capacity to stimulate collagen production. RJ has attracted interest in various parts of the world for its pharmacological properties. However, the effects of RJ on ultraviolet (UV)-induced photoaging of the skin have not been reported. In this study we measured the 10-HDA content of RJ by high-performance liquid chromatography and tested the effects of RJ on UVB-induced skin photoaging in normal human dermal fibroblasts. The effects of RJ and 10-HDA on UVB-induced photoaging were tested by measuring procollagen type I, transforming growth factor (TGF)-β1, and matrix metalloproteinase (MMP)-1 after UVB irradiation. The RJ contained about 0.211% 10-HDA. The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-β1 productions, but the level of MMP-1 was not changed. Thus RJ may potentially protect the skin from UVB-induced photoaging by enhancing collagen production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apitherapy
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Collagen Type I / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Fatty Acids / adverse effects
  • Fatty Acids / chemistry
  • Fatty Acids / pharmacology*
  • Fatty Acids, Monounsaturated / adverse effects
  • Fatty Acids, Monounsaturated / analysis
  • Fatty Acids, Monounsaturated / pharmacology
  • Humans
  • Matrix Metalloproteinase 1 / metabolism
  • Osmolar Concentration
  • Procollagen / metabolism
  • Republic of Korea
  • Skin / drug effects*
  • Skin / metabolism*
  • Skin / pathology
  • Skin / radiation effects
  • Skin Aging / drug effects*
  • Skin Aging / pathology
  • Sunscreening Agents / analysis
  • Sunscreening Agents / chemistry
  • Sunscreening Agents / pharmacology*
  • Transforming Growth Factor beta1 / metabolism
  • Ultraviolet Rays / adverse effects
  • Up-Regulation / drug effects*


  • Collagen Type I
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Procollagen
  • Sunscreening Agents
  • TGFB1 protein, human
  • Transforming Growth Factor beta1
  • 10-hydroxy-2-decenoic acid
  • MMP1 protein, human
  • Matrix Metalloproteinase 1
  • royal jelly