ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia

Leuk Res. 2011 Oct;35(10):1390-4. doi: 10.1016/j.leukres.2011.06.021. Epub 2011 Aug 2.


ROR1 is a receptor tyrosine kinase expressed during embryogenesis, on chronic lymphocytic leukemia (CLL) and in other malignancies. Hematogones (non-neoplastic B-lymphocyte precursors) express surface ROR1 at an intermediate stage of maturation that lacks CD34 or TdT. The neoplastic counterpart to hematogones is precursor-B acute lymphoblastic leukemia (B-ALL), but less than 10% of B-ALL express surface ROR1, and these ROR1+ B-ALL cases have an unusually high frequency of lacking CD34 and/or having t(1;19), a chromosomal translocation that defines a specific subtype of B-ALL.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antigens, CD / analysis
  • Antigens, CD / biosynthesis
  • Bone Marrow / metabolism*
  • Bone Marrow / pathology
  • Flow Cytometry
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunophenotyping
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Precursor Cells, B-Lymphoid / metabolism*
  • Precursor Cells, B-Lymphoid / pathology
  • Receptor Tyrosine Kinase-like Orphan Receptors* / genetics
  • Receptor Tyrosine Kinase-like Orphan Receptors* / metabolism
  • Translocation, Genetic


  • Antigens, CD
  • ROR1 protein, human
  • Receptor Tyrosine Kinase-like Orphan Receptors