Three kidneys, two diseases, one antibody?

Nephrol Dial Transplant. 2011 Nov;26(11):3811-3. doi: 10.1093/ndt/gfr436. Epub 2011 Aug 3.


Anti-factor H antibody has been recently described as responsible for thrombotic microangiopathies (TMA) as well as membranoproliferative glomerulonephritis (MPGN). We report here, for the first time, the case of a woman with an anti-factor H antibody, who developed MPGN on native kidney, rapid recurrence on first graft, and TMA on second graft despite immunosuppressive therapy and plasma exchanges. This case supports the hypothesis that MPGN and TMA are closely linked by common pathogenic mechanisms and the need for complete exploration of complement pathway including factor H activity and autoantibody in front of any MPGN.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Anti-Idiotypic / immunology
  • Atypical Hemolytic Uremic Syndrome
  • Autoantibodies / immunology*
  • Complement C3 / immunology
  • Complement Factor H / immunology*
  • Female
  • Glomerular Filtration Rate
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Glomerulonephritis, Membranoproliferative / therapy
  • Graft Rejection / etiology
  • Graft Rejection / therapy
  • Hemolytic-Uremic Syndrome / etiology*
  • Hemolytic-Uremic Syndrome / therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / therapy*
  • Kidney Function Tests
  • Kidney Transplantation / adverse effects*
  • Prognosis
  • Purpura, Thrombotic Thrombocytopenic / etiology*
  • Purpura, Thrombotic Thrombocytopenic / therapy


  • Antibodies, Anti-Idiotypic
  • Autoantibodies
  • Complement C3
  • Immunosuppressive Agents
  • Complement Factor H