The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in systemic inflammatory response syndrome

Clin Biochem. 2011 Oct;44(14-15):1227-30. doi: 10.1016/j.clinbiochem.2011.07.006. Epub 2011 Jul 26.

Abstract

Objectives: This study was intended to investigate the value of suPAR, C-reactive protein (CRP) and procalcitonin (PCT) in the determination and prognosis of systemic inflammatory response syndrome (SIRS) patients.

Methods: The study was performed among patients with at least two SIRS criteria. PCT, CRP and suPAR were analyzed from the blood specimens taken.

Results: Eighty-five patients were enrolled in the SIRS group (44 bacteremia, 20 urinary tract infection, 12 pneumonia and 9 non-infection), and 53 individuals in the control group. A significant correlation was determined between suPAR, PCT and CRP values in both groups (P<0.0001). A suPAR cutoff value of 2.8ng/mL was associated with an NPV of 87% and PPV of 91%, with 92% sensitivity and 85% specificity. A relatively high suPAR level that might predict fatality was also determined in fatal cases (P=0.001).

Conclusion: suPAR possesses high sensitivity and specificity levels in terms of differential diagnosis, and high suPAR levels can predict fatality.

MeSH terms

  • Adult
  • Bacteremia / complications
  • Biomarkers / blood
  • C-Reactive Protein / metabolism*
  • Calcitonin / blood*
  • Calcitonin Gene-Related Peptide
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pneumonia / complications
  • Predictive Value of Tests
  • Prognosis
  • Protein Precursors / blood*
  • Receptors, Urokinase Plasminogen Activator / blood*
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / diagnosis*
  • Systemic Inflammatory Response Syndrome / etiology
  • Systemic Inflammatory Response Syndrome / mortality
  • Urinary Tract Infections / complications

Substances

  • Biomarkers
  • CALCA protein, human
  • Protein Precursors
  • Receptors, Urokinase Plasminogen Activator
  • Calcitonin
  • C-Reactive Protein
  • Calcitonin Gene-Related Peptide