Expanding the genetic code of an animal

J Am Chem Soc. 2011 Sep 14;133(36):14196-9. doi: 10.1021/ja2054034. Epub 2011 Aug 22.


Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / genetics*
  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / genetics*
  • DNA, Bacterial / genetics
  • Genetic Code*


  • Amino Acids
  • Caenorhabditis elegans Proteins
  • DNA, Bacterial