Morphological studies of the murine heart based on probabilistic and statistical atlases

Comput Med Imaging Graph. 2012 Mar;36(2):119-29. doi: 10.1016/j.compmedimag.2011.07.001. Epub 2011 Aug 5.


This study directly compares morphological features of the mouse heart in its end-relaxed state based on constructed morphometric maps and atlases using principal component analysis in C57BL/6J (n=8) and DBA (n=5) mice. In probabilistic atlases, a gradient probability exists for both strains in longitudinal locations from base to apex. Based on the statistical atlases, differences in size (49.8%), apical direction (15.6%), basal ventricular blood pool size (13.2%), and papillary muscle shape and position (17.2%) account for the most significant modes of shape variability for the left ventricle of the C57BL/6J mice. For DBA mice, differences in left ventricular size and direction (67.4%), basal size (15.7%), and position of papillary muscles (16.8%) account for significant variability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Animals
  • Contrast Media
  • Data Interpretation, Statistical
  • Gadolinium DTPA*
  • Heart / anatomy & histology*
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*


  • Contrast Media
  • Gadolinium DTPA