Moving in the right direction: how eukaryotic cells migrate along chemical gradients

Semin Cell Dev Biol. 2011 Oct;22(8):834-41. doi: 10.1016/j.semcdb.2011.07.020. Epub 2011 Jul 28.


Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement* / drug effects
  • Chemotactic Factors / metabolism*
  • Chemotactic Factors / pharmacology
  • Cytoskeleton / drug effects
  • Cytoskeleton / metabolism
  • Eukaryotic Cells / cytology*
  • Eukaryotic Cells / drug effects
  • Humans
  • Intracellular Space / drug effects
  • Intracellular Space / metabolism
  • Signal Transduction / drug effects


  • Chemotactic Factors