An encapsulated fruit and vegetable juice concentrate increases skin microcirculation in healthy women

Skin Pharmacol Physiol. 2012;25(1):2-8. doi: 10.1159/000330521. Epub 2011 Aug 5.


Background/aim: Microcirculation in the dermis of the skin is important for nutrient delivery to this tissue. In this study, the effects of a micronutrient concentrate (Juice Plus+®; 'active group'), composed primarily of fruit and vegetable juice powder, on skin microcirculation and structure were compared to placebo.

Study design/methods: This 12-week study had a monocentric, double-blind placebo and randomized controlled design with two treatment groups consisting of 26 healthy middle-aged women each. The 'oxygen to see' device was used to evaluate microcirculation. Skin density and thickness were measured using ultrasound. Measurements for skin hydration (Corneometer®), transepidermal water loss and serum analysis for carotenoids and α-tocopherol were also performed.

Results: By 12 weeks, microcirculation of the superficial plexus increased by 39%. Furthermore, skin hydration increased by 9% while skin thickness increased by 6% and skin density by 16% in the active group. In the placebo group, microcirculation decreased, and a slight increase in skin density was observed.

Conclusion: Ingestion of a fruit- and vegetable-based concentrate increases microcirculation of the skin at 12 weeks of intervention and positively affects skin hydration, density and thickness.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carotenoids / blood
  • Carotenoids / pharmacokinetics
  • Carotenoids / pharmacology
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Fruit*
  • Humans
  • Microcirculation / drug effects*
  • Micronutrients / blood
  • Micronutrients / pharmacokinetics
  • Micronutrients / pharmacology
  • Middle Aged
  • Skin / blood supply
  • Skin / diagnostic imaging
  • Skin / drug effects*
  • Ultrasonography
  • Vegetables*
  • alpha-Tocopherol / blood
  • alpha-Tocopherol / pharmacokinetics
  • alpha-Tocopherol / pharmacology


  • Micronutrients
  • Carotenoids
  • alpha-Tocopherol