Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

Nat Genet. 2011 Aug 7;43(9):828-9. doi: 10.1038/ng.903.

Abstract

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / virology*
  • Chromatin / metabolism*
  • Female
  • Gene Silencing
  • Hepatitis C, Chronic / complications*
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / virology*
  • Male
  • Middle Aged
  • Mutation
  • Transcription Factors / genetics*

Substances

  • ARID2 protein, human
  • Chromatin
  • Transcription Factors