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Meta-Analysis
. 2011 Nov;26(11):1375-85.
doi: 10.1007/s00384-011-1281-x. Epub 2011 Aug 6.

Laparoscopic Versus Conventional Open Surgery for Immune Function in Patients With Colorectal Cancer

Affiliations
Meta-Analysis

Laparoscopic Versus Conventional Open Surgery for Immune Function in Patients With Colorectal Cancer

Chuanyuan Liu et al. Int J Colorectal Dis. .

Abstract

Objective: To systematically evaluate the immune function in patients with colorectal cancer after laparoscopic surgery (LS) and conventional open surgery (OS).

Methods: PUBMED, EMBASE, and the Cochrane library were searched and randomized controlled trials (RCTs) comparing the immunological difference between LS and OS were included. Two authors extracted data and assessed trial quality.

Results: Eleven studies including 695 patients were analysed. Immune-competent cells demonstrated no significant differences between LS and OS in six trials. Eight trials assessed various perioperative plasma cytokine concentrations with no significant differences in interleukin-6 (IL-6) and C-reactive protein (CRP) levels between LS and OS. However, meta-analysis showed higher T suppressor lymphocytes (CD8+) counts on postoperative days (POD) 1-3 and lower plasma levels of CRP on POD 0-1 in LS group compared with OS group.

Conclusion: Although LS groups displayed higher T suppressor lymphocyte (CD8+) counts on postoperative days (POD) 1-3 and lower plasma levels of CRP on POD 0-1, there is no sufficient evidence to support superior preservation of global immune function with LS compared to OS.

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