The regulatory function of SPARC in vascular biology

Cell Mol Life Sci. 2011 Oct;68(19):3165-73. doi: 10.1007/s00018-011-0781-8. Epub 2011 Aug 6.


SPARC is a matricellular protein, able to modulate cell/ECM interactions and influence cell responses to growth factors, and therefore is particularly attuned to contribute to physiological processes involving changes in ECM and cell mobilization. Indeed, the list of biological processes affected by SPARC includes wound healing, tumor progression, bone formation, fibrosis, and angiogenesis. The process of angiogenesis is complex and involves a number of cellular processes such as endothelial cell proliferation, migration, ECM degradation, and synthesis, as well as pericyte recruitment to stabilize nascent vessels. In this review, we will summarize current results that explore the function of SPARC in the regulation of angiogenic events with a particular emphasis on the modulation of growth factor activity by SPARC in the context of blood vessel formation. The primary function of SPARC in angiogenesis remains unclear, as SPARC activity in some circumstances promotes angiogenesis and in others is more consistent with an anti-angiogenic activity. Undoubtedly, the mercurial nature of SPARC belies a redundancy of functional proteins in angiogenesis as well as cell-type-specific activities that alter signal transduction events in response to unique cellular milieus. Nonetheless, the investigation of cellular mechanisms that define functional activities of SPARC continue to contribute novel and exciting paradigms to vascular biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix Proteins / chemistry
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / physiology*
  • Fibroblast Growth Factor 2 / metabolism
  • Fibroblast Growth Factor 2 / physiology
  • Humans
  • Integrin alphaV / metabolism
  • Mice
  • Neovascularization, Physiologic / genetics
  • Neovascularization, Physiologic / physiology*
  • Osteonectin / chemistry
  • Osteonectin / genetics
  • Osteonectin / physiology*
  • Signal Transduction
  • Transforming Growth Factor beta1 / metabolism
  • Transforming Growth Factor beta1 / physiology
  • Vascular Endothelial Growth Factor A / metabolism
  • Vascular Endothelial Growth Factor A / physiology


  • Extracellular Matrix Proteins
  • Integrin alphaV
  • Osteonectin
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factor 2