Benign transient hyperphosphatasemia in infants and children: a prospective cohort

J Pediatr Endocrinol Metab. 2011;24(5-6):351-3.


A total of 20 children with benign transient hyperphosphatasemia were prospectively evaluated with no additional investigations recommended except repeat serologic evaluation in 2-3 months. The average age of our patients was 2.5 years (range 1 year 2 months-5 years 10 months). The serum levels of alkaline phosphatase averaged 2383 IU/L (range 1013-5700 IU/L). Levels returned to normal within several months. This condition should be recognized by the clinician in order not to put patients through lengthy, expensive and unnecessary investigations.

MeSH terms

  • Alkaline Phosphatase / blood*
  • Bone and Bones / enzymology
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant
  • Isoenzymes / blood
  • Liver / enzymology
  • Male
  • Prospective Studies
  • Time Factors


  • Isoenzymes
  • Alkaline Phosphatase