New insights into the phylogenetic distribution and evolutionary origins of the septins

Biol Chem. 2011 Aug;392(8-9):681-7. doi: 10.1515/BC.2011.086.


Until recently, it had appeared that the septin family of proteins was restricted to the opisthokont eukaryotes (the fungi and animals and their close relatives the microsporidia and choanoflagellates). It has now become apparent that septins are also present in several other widely divergent eukaryotic lineages (chlorophyte algae, brown algae, and ciliates). This distribution and the details of the non-opisthokont septin sequences appear to require major revisions to hypotheses about the origins and early evolution of the septins.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chlorophyta / genetics
  • Chlorophyta / metabolism
  • Evolution, Molecular*
  • Molecular Sequence Data
  • Phaeophyceae / genetics
  • Phaeophyceae / metabolism
  • Phylogeny*
  • Septins / chemistry*
  • Septins / classification*
  • Septins / genetics
  • Septins / metabolism
  • Sequence Homology, Amino Acid


  • Septins