Taking a "good" look at free radicals in the aging process

Trends Cell Biol. 2011 Oct;21(10):569-76. doi: 10.1016/j.tcb.2011.06.008. Epub 2011 Aug 6.


The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based on the observed association of the rate of aging and the aged phenotype with the generation of ROS and oxidative damage. However, recent findings, in particular in Caenorhabditis elegans but also in rodents, suggest that ROS generation is not the primary or initial cause of aging. Here, we propose that ROS are tightly associated with aging because they play a role in mediating a stress response to age-dependent damage. This could generate the observed correlation between aging and ROS without implying that ROS damage is the earliest trigger or main cause of aging.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Caenorhabditis elegans / metabolism
  • DNA Damage*
  • Free Radicals / chemistry
  • Free Radicals / metabolism*
  • Humans
  • Mitochondria / metabolism*
  • Models, Molecular*
  • Mutation / genetics
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism*
  • Rodentia / metabolism
  • Signal Transduction
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism


  • Free Radicals
  • Reactive Oxygen Species
  • Superoxide Dismutase

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