Transcription of ncDNA: Many roads lead to local gene regulation

Transcription. 2011 May;2(3):120-123. doi: 10.4161/trns.2.3.15684.


Transcription of ncDNA occurs throughout eukaryotic genomes, generating a wide array of ncRNAs. One large class of ncRNAs includes those transcribed over the promoter regions of nearby protein coding genes. Recent studies, primarily focusing on individual genes have uncovered multiple mechanisms by which promoter-associated transcriptional activity locally alters gene expression.