Side-effects of local hyperthermia: results of a prospectively randomized clinical study

Int J Hyperthermia. 1990 Mar-Apr;6(2):279-85. doi: 10.3109/02656739009141138.


In 1986, 25 patients with stage II and III carcinoma of the cervix were treated by a combination of radiation and local hyperthermia using an endotract intravaginal applicator. Another 25 patients were treated with radiation alone. Both groups were followed up for a minimum period of 18 months. The acute and long-term toxicity of local hyperthermia was closely monitored. Our study shows that whereas local hyperthermia adds significantly to the local control achieved with radiation alone, it is not in any way associated with any significant short- or long-term toxicity, and does not enhance the radiation reactions.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Combined Modality Therapy
  • Female
  • Hot Temperature / adverse effects*
  • Hot Temperature / therapeutic use
  • Humans
  • Middle Aged
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Uterine Cervical Neoplasms / radiotherapy
  • Uterine Cervical Neoplasms / therapy*