An OHSS-Free Clinic by segmentation of IVF treatment

Hum Reprod. 2011 Oct;26(10):2593-7. doi: 10.1093/humrep/der251. Epub 2011 Aug 9.


Published data indicate a significant increase in ovarian hyperstimulation syndrome globally. The occurrence of approximately three maternal deaths per 100,000 stimulated women has been reported, and extrapolation of these figures to a global situation would give an impressive number. The syndrome can be erased by applying ovarian stimulation using the combination of GnRH antagonist with GnRH agonist to trigger ovulation. In this case, the strategy is to freeze all of the oocytes or embryos for later use.

Publication types

  • Review

MeSH terms

  • Birth Rate
  • Cryopreservation / methods*
  • Female
  • Fertilization in Vitro / methods*
  • Gonadotropin-Releasing Hormone / metabolism
  • Humans
  • Oocytes / cytology
  • Oocytes / metabolism
  • Ovarian Hyperstimulation Syndrome / epidemiology*
  • Ovulation
  • Ovulation Induction
  • Reproductive Techniques, Assisted


  • Gonadotropin-Releasing Hormone