Ethnic differences in prostate cancer

Br J Cancer. 2011 Aug 9;105(4):481-5. doi: 10.1038/bjc.2011.273.

Abstract

Background: It is recognised that the risk of prostate cancer is higher in black men than in white men worldwide. Recent studies suggest that a number of genetic mutations in black men predispose them to this disease; hence, race as well as environmental factors such as diet and migration are thought to be the determining factors.

Methods: This review compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries.

Conclusions: Studies from the United States and the United Kingdom came to significantly different conclusions, and this has implications for policy development, awareness raising among black men in each country and clinical practice.

Publication types

  • Comparative Study

MeSH terms

  • Africa / ethnology
  • African Americans / statistics & numerical data*
  • African Continental Ancestry Group / statistics & numerical data*
  • Aged
  • Aged, 80 and over
  • Caribbean Region / ethnology
  • Cost of Illness
  • Dietary Fats / administration & dosage
  • Dietary Fats / adverse effects
  • European Continental Ancestry Group / statistics & numerical data
  • Feeding Behavior
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prevalence
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / ethnology*
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / mortality
  • Reproducibility of Results
  • Research Design
  • Risk Factors
  • Testosterone / blood
  • United Kingdom / epidemiology
  • United States / epidemiology

Substances

  • Dietary Fats
  • Testosterone