The influence of probiotic Enterococcus faecium strain L5 on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics

Benef Microbes. 2010 Sep;1(3):265-70. doi: 10.3920/BM2010.0008.

Abstract

The animal model of intestinal dysbiosis induced by antibiotics was created. Dysbiotic condition was confirmed by the changes in titre of the indigenous microbiota (excessive growth of opportunistic microorganisms and reduced number of lactobacilli, bifidobacteria and enterococci) and the appearance of dyspeptic symptoms. Consumption of the fermented milk product with probiotic strain Enterococcus faecium L5 led to the rapid disappearance of dysbiosis symptoms, normalisation of the microbiota, increase in expression of IL-10 and decrease in IL-8 expression.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / adverse effects*
  • Disease Models, Animal
  • Enterococcus faecium / growth & development*
  • Enterococcus faecium / isolation & purification
  • Female
  • Humans
  • Interleukin-10 / genetics*
  • Interleukin-10 / immunology
  • Interleukin-8 / genetics*
  • Interleukin-8 / immunology
  • Intestinal Diseases / chemically induced
  • Intestinal Diseases / drug therapy*
  • Intestinal Diseases / immunology
  • Intestinal Diseases / microbiology
  • Intestines / immunology
  • Intestines / microbiology*
  • Male
  • Metagenome*
  • Probiotics / administration & dosage*
  • Rats
  • Rats, Wistar

Substances

  • Anti-Bacterial Agents
  • Interleukin-8
  • Interleukin-10