Assessing vitamin D status

Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):440-4. doi: 10.1097/MCO.0b013e328348ed85.


Purpose of review: To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status.

Recent findings: Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease.

Conclusion: The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).

Publication types

  • Review

MeSH terms

  • Health Status*
  • Humans
  • Nutrition Assessment*
  • Nutritional Status*
  • Reference Values
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood*
  • Vitamin D / toxicity
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / diagnosis


  • Vitamin D
  • 25-hydroxyvitamin D