Abstract
Cyclopenicillone (1), possessing a unique 2,5-dimethylcyclopent-2-enone carbon skeleton, has been isolated from the cultures broth of the fungus Penicillium decumbens. The structure and absolute configuration of 1 were elucidated using a combination of NMR spectroscopy, CD data and computational approaches. Cyclopenicillone (1) demonstrated a dose-dependent (10-100 μM) inhibition against LPS-induced NO production in RAW264.7 macrophages.
This journal is © The Royal Society of Chemistry 2011
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line
-
Culture Techniques*
-
Cyclopentanes / chemistry*
-
Cyclopentanes / isolation & purification
-
Cyclopentanes / metabolism
-
Cyclopentanes / pharmacology
-
Lipopolysaccharides / pharmacology
-
Macrophages / drug effects
-
Macrophages / metabolism
-
Models, Molecular
-
Molecular Conformation
-
Nitric Oxide / biosynthesis
-
Penicillium / growth & development*
-
Penicillium / metabolism
Substances
-
Cyclopentanes
-
Lipopolysaccharides
-
cyclopenicillone
-
Nitric Oxide
-
cyclopentenone