Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage

C Alafaci; I Jansen; M A Arbab; Y Shiokawa; N A Svendgaard; L Edvinsson

doi:10.1111/j.1748-1716.1990.tb08852.x

Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage

Acta Physiol Scand. 1990 Mar;138(3):317-9. doi: 10.1111/j.1748-1716.1990.tb08852.x.

Authors

C Alafaci¹, I Jansen, M A Arbab, Y Shiokawa, N A Svendgaard, L Edvinsson

Affiliation

¹ Department of Experimental Research, University of Lund, Sweden.

PMID: 2183539
DOI: 10.1111/j.1748-1716.1990.tb08852.x

Abstract

The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cerebral Arteries / drug effects*
Cerebral Arteries / physiopathology
Endothelins
Endothelium, Vascular / physiology
In Vitro Techniques
Peptides / pharmacology*
Peptides / physiology
Rats
Rats, Inbred Strains
Subarachnoid Hemorrhage / physiopathology*
Vasoconstriction / drug effects
Vasoconstriction / physiology*
Vasoconstrictor Agents

Substances

Endothelins
Peptides
Vasoconstrictor Agents