Contribution of myo-inositol and melatonin to human reproduction

Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):267-72. doi: 10.1016/j.ejogrb.2011.07.038. Epub 2011 Aug 10.


Diet is a critical factor for the development of both embryo and fetus, as well as maternal health. In particular, two natural molecules have been shown to exert beneficial effects on fertility, pregnancy wellness and embryo development: myo-inositol and melatonin, whose requirements increase during pregnancy. In the present review, we summarize the most important functions of melatonin and myo-inositol on male and female reproductive systems (oocyte quality and development, sperm quality), on the maintenance of a physiological pregnancy and on embryo development.

Publication types

  • Review

MeSH terms

  • Diet* / adverse effects
  • Dietary Supplements
  • Embryonic Development
  • Female
  • Humans
  • Inositol / administration & dosage
  • Inositol / metabolism*
  • Inositol / therapeutic use
  • Inositol Phosphates / metabolism
  • Male
  • Maternal Nutritional Physiological Phenomena
  • Melatonin / administration & dosage
  • Melatonin / metabolism*
  • Melatonin / therapeutic use
  • Oogenesis*
  • Phosphatidylinositol Phosphates / metabolism
  • Pregnancy
  • Pregnancy Maintenance*
  • Spermatogenesis*


  • Inositol Phosphates
  • Phosphatidylinositol Phosphates
  • Inositol
  • Melatonin