Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study

Stroke. 2011 Sep;42(9):2611-4. doi: 10.1161/STROKEAHA.111.614313. Epub 2011 Aug 11.


Background and purpose: Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians.

Methods: A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions).

Results: The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex.

Conclusions: Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Asian Continental Ancestry Group*
  • Blood Glucose / metabolism
  • Brain Infarction / blood
  • Brain Infarction / classification
  • Brain Infarction / epidemiology*
  • Brain Infarction / etiology
  • Data Collection*
  • Diabetes Complications / blood
  • Diabetes Complications / epidemiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Risk Factors
  • Stroke / blood
  • Stroke / classification
  • Stroke / epidemiology*
  • Stroke / etiology


  • Blood Glucose