Lateral ridge augmentation using an equine flex bone block infused with recombinant human platelet-derived growth factor BB: a clinical and histologic study

Int J Periodontics Restorative Dent. 2011 Jul-Aug;31(4):383-8.


This paper reports on a patient who underwent horizontal ridge augmentation using recombinant human platelet-derived growth factor BB (rhPDGF-BB) in combination with a collagenate equine block. Ninety days after the first surgery, 8 mm of new bone was noted on a computed tomography scan, and three 5-mm implants were placed. Histology, performed using confocal laser scanning microscopy, showed a large amount of newly formed bone well characterized with osteon and resorption lacunae, which demonstrated the intense bone remodeling. This study supports the use of rhPDGF-BB in combination with allograft blocks.

Publication types

  • Case Reports

MeSH terms

  • Alveolar Ridge Augmentation / methods*
  • Angiogenesis Inducing Agents / therapeutic use*
  • Animals
  • Becaplermin
  • Bone Remodeling / physiology
  • Bone Resorption / pathology
  • Bone Transplantation / methods*
  • Bone Transplantation / pathology
  • Dental Implantation, Endosseous
  • Follow-Up Studies
  • Haversian System / pathology
  • Horses
  • Humans
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Osteogenesis / physiology
  • Proto-Oncogene Proteins c-sis / therapeutic use*
  • Recombinant Proteins
  • Tomography, X-Ray Computed
  • Transplantation, Heterologous*


  • Angiogenesis Inducing Agents
  • Proto-Oncogene Proteins c-sis
  • Recombinant Proteins
  • Becaplermin