Relationship between endometriosis and cancer from current perspective

Arch Gynecol Obstet. 2011 Dec;284(6):1473-9. doi: 10.1007/s00404-011-2047-y. Epub 2011 Aug 12.


Purpose: To examine the current mechanisms of the increased incidence of cancer in women with endometriosis.

Methods: The synthesis and review of the relevant current literature in English language.

Results: Compared with general population, women with endometriosis have two times higher risk for developing ovarian cancer, 30% higher risk for developing breast cancer, and 40% higher risk for developing hematopoietic malignancies, mainly non-Hodgkin lymphoma.

Conclusions: Endometriosis comprises many predisposing factors including genetic, epigenetic, local environmental, hormonal, inflammatory and immunologic changes, for the development of some cancers.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / physiopathology*
  • Endometriosis / physiopathology*
  • Female
  • Hematologic Neoplasms / physiopathology*
  • Humans
  • Ovarian Neoplasms / physiopathology*
  • Risk Factors