ERp57/GRP58: a protein with multiple functions

Cell Mol Biol Lett. 2011 Dec;16(4):539-63. doi: 10.2478/s11658-011-0022-z. Epub 2011 Aug 11.


The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Biological
  • Animals
  • Calcitriol / genetics
  • Calcitriol / metabolism
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • DNA / metabolism
  • DNA Repair / genetics
  • Endoplasmic Reticulum / genetics
  • Endoplasmic Reticulum / metabolism*
  • Gene Expression Regulation*
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Mice
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Protein Binding
  • Protein Disulfide-Isomerases / genetics
  • Protein Disulfide-Isomerases / metabolism*
  • Protein Structure, Tertiary
  • Rats
  • STAT3 Transcription Factor / genetics
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction / genetics*
  • Stress, Physiological


  • Histocompatibility Antigens Class I
  • Molecular Chaperones
  • STAT3 Transcription Factor
  • DNA
  • Pdia3 protein, mouse
  • Protein Disulfide-Isomerases
  • PDIA3 protein, human
  • Calcitriol