Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues

J Am Chem Soc. 2011 Sep 14;133(36):14228-31. doi: 10.1021/ja206229y. Epub 2011 Aug 22.

Abstract

A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzodiazepines / chemical synthesis*
  • Benzodiazepines / chemistry
  • Catalysis
  • Oxazepines
  • Palladium / chemistry*

Substances

  • Oxazepines
  • Benzodiazepines
  • Palladium