Differentiation of intercalated cells in the kidney

Physiology (Bethesda). 2011 Aug;26(4):266-72. doi: 10.1152/physiol.00008.2011.


The intercalated cell of collecting ducts of the kidney is of two forms, the α form secretes acid, whereas the β form secretes HCO(3). Here, we review recent work that shows that the α form is derived from the β form and that the pathway is mediated by an extracellular matrix protein called hensin/DMBT1.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Extracellular Matrix Proteins / metabolism
  • Humans
  • Kidney / cytology*
  • Kidney / metabolism
  • Kidney Tubules, Collecting / cytology
  • Kidney Tubules, Collecting / metabolism


  • Extracellular Matrix Proteins